General Information

  • ID:  hor001791
  • Uniprot ID:  P83349
  • Protein name:  FMRFamide-18
  • Gene name:  NA
  • Organism:  Sarcophaga bullata (Grey flesh fly) (Neobellieria bullata)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Neobellieria (subgenus), Sarcophaga (genus), Sarcophaginae (subfamily), Sarcophagidae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APPQPSDNFIRF
  • Length:  12
  • Propeptide:  APPQPSDNFIRF
  • Signal peptide:  NA
  • Modification:  T12 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has modulatory actions at skeletal neuromuscular junctions.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001791_AF2.pdbhor001791_ESM.pdb

Physical Information

Mass: 158492 Formula: C64H93N17O18
Absent amino acids: CEGHKLMTVWY Common amino acids: P
pI: 6.34 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: -72.5 Boman Index: -2653
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 40.83
Instability Index: 7689.17 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  12438685
  • Title:  Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor.
  • PubMed ID:  18789334
  • Title:  Extended FMRFamides in dipteran insects: conservative expression in the neuroendocrine system is accompanied by rapid sequence evolution.